Doug Yao’s paper (with Luke O’Connor and Alkes Price) on MESC, a new method for estimating the fraction of total disease heritability is mediated by gene expression QTLs is now out in Nature Genetics:

Quantifying genetic effects on disease mediated by assayed gene expression levels. D Yao, LJ O’Connor, AL Price, A Gusev. Nature Genetics. 2020

Doug’s (must read!) twitter thread summarizing the findings is here and the method/code is available in this repository. A previous summary of the pre-print is here.


mediated hsq

Fig. 1: Schematic of MESC.